Influenza B-cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines
Identifieur interne : 000A50 ( Main/Exploration ); précédent : 000A49; suivant : 000A51Influenza B-cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines
Auteurs : Nicola Clementi ; Elena Criscuolo ; Matteo Castelli ; Nicasio Mancini ; Massimo Clementi ; Roberto BurioniSource :
- Viruses [ 1999-4915 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Anticorps monoclonaux (immunologie), Anticorps neutralisants (immunologie), Antigènes viraux (), Antigènes viraux (immunologie), Déterminants antigéniques des lymphocytes B (), Déterminants antigéniques des lymphocytes B (immunologie), Glycoprotéine hémagglutinine du virus influenza (), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (), Grippe humaine (immunologie), Humains, Lymphocytes B (immunologie), Réactions croisées (immunologie), Vaccins antigrippaux (immunologie), Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (immunologie).
- MESH :
- génétique : Virus de la grippe A.
- immunologie : Anticorps monoclonaux, Anticorps neutralisants, Antigènes viraux, Déterminants antigéniques des lymphocytes B, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Lymphocytes B, Réactions croisées, Vaccins antigrippaux, Virus de la grippe A.
- Animaux, Antigènes viraux, Déterminants antigéniques des lymphocytes B, Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Humains, Virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Antibodies, Monoclonal (immunology), Antibodies, Neutralizing (immunology), Antigens, Viral (chemistry), Antigens, Viral (immunology), B-Lymphocytes (immunology), Cross Reactions (immunology), Epitopes, B-Lymphocyte (chemistry), Epitopes, B-Lymphocyte (immunology), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (immunology), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control).
- MESH :
- chemical , chemistry : Antigens, Viral, Epitopes, B-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Neutralizing, Antigens, Viral, Epitopes, B-Lymphocyte, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines.
- classification : Influenza A virus.
- genetics : Influenza A virus.
- immunology : B-Lymphocytes, Cross Reactions, Influenza A virus, Influenza, Human.
- prevention & control : Influenza, Human.
- Animals, Humans.
Abstract
The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and “universal” anti-influenza vaccines.
Url:
DOI: 10.3390/v4113090
PubMed: 23202517
PubMed Central: 3509685
Affiliations:
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Le document en format XML
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last="Clementi">Nicola Clementi</name></author><author><name sortKey="Criscuolo, Elena" sort="Criscuolo, Elena" uniqKey="Criscuolo E" first="Elena" last="Criscuolo">Elena Criscuolo</name></author><author><name sortKey="Castelli, Matteo" sort="Castelli, Matteo" uniqKey="Castelli M" first="Matteo" last="Castelli">Matteo Castelli</name></author><author><name sortKey="Mancini, Nicasio" sort="Mancini, Nicasio" uniqKey="Mancini N" first="Nicasio" last="Mancini">Nicasio Mancini</name></author><author><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name></author><author><name sortKey="Burioni, Roberto" sort="Burioni, Roberto" uniqKey="Burioni R" first="Roberto" last="Burioni">Roberto Burioni</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date 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xml:lang="fr"><term>Animaux</term><term>Anticorps monoclonaux (immunologie)</term><term>Anticorps neutralisants (immunologie)</term><term>Antigènes viraux ()</term><term>Antigènes viraux (immunologie)</term><term>Déterminants antigéniques des lymphocytes B ()</term><term>Déterminants antigéniques des lymphocytes B (immunologie)</term><term>Glycoprotéine hémagglutinine du virus influenza ()</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe humaine ()</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Lymphocytes B (immunologie)</term><term>Réactions croisées (immunologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A ()</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes, B-Lymphocyte</term><term>Hemagglutinin 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B</term><term>Réactions croisées</term><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>B-Lymphocytes</term><term>Cross Reactions</term><term>Influenza A virus</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antigènes viraux</term><term>Déterminants antigéniques des lymphocytes B</term><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe humaine</term><term>Humains</term><term>Virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The emergence of new influenza strains causing pandemics represents a serious threat to human health. From 1918, four influenza pandemics occurred, caused by H1N1, H2N2 and H3N2 subtypes. Moreover, in 1997 a novel influenza avian strain belonging to the H5N1 subtype infected humans. Nowadays, even if its transmission is still circumscribed to avian species, the capability of the virus to infect humans directly from avian reservoirs can result in fatalities. Moreover, the risk that this or novel avian strains could adapt to inter-human transmission, the development of resistance to anti-viral drugs and the lack of an effective prevention are all incumbent problems for the world population. In this scenario, the identification of broadly neutralizing monoclonal antibodies (mAbs) directed against conserved regions shared among influenza isolates has raised hopes for the development of monoclonal antibody-based immunotherapy and “universal” anti-influenza vaccines.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, M T" uniqKey="Osterholm M">M.T. Osterholm</name></author><author><name sortKey="Henderson, D A" uniqKey="Henderson D">D.A. Henderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R. Fouchier</name></author><author><name sortKey="Osterhaus, A B" uniqKey="Osterhaus A">A.B. Osterhaus</name></author><author><name sortKey="Steinbruner, J" uniqKey="Steinbruner J">J. 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He</name></author><author><name sortKey="Yu, S Q" uniqKey="Yu S">S.Q. Yu</name></author><author><name sortKey="Zhang, H B" uniqKey="Zhang H">H.B. Zhang</name></author><author><name sortKey="Fan, H J" uniqKey="Fan H">H.J. Fan</name></author><author><name sortKey="Lu, C P" uniqKey="Lu C">C.P. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hall, T A" uniqKey="Hall T">T.A. Hall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Group, W O F H N E W" uniqKey="Group W">W.O.F.H.N.E.W. Group</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Burioni, Roberto" sort="Burioni, Roberto" uniqKey="Burioni R" first="Roberto" last="Burioni">Roberto Burioni</name><name sortKey="Castelli, Matteo" sort="Castelli, Matteo" uniqKey="Castelli M" first="Matteo" last="Castelli">Matteo Castelli</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="Clementi, Nicola" sort="Clementi, Nicola" uniqKey="Clementi N" first="Nicola" last="Clementi">Nicola Clementi</name><name sortKey="Criscuolo, Elena" sort="Criscuolo, Elena" uniqKey="Criscuolo E" first="Elena" last="Criscuolo">Elena Criscuolo</name><name sortKey="Mancini, Nicasio" sort="Mancini, Nicasio" uniqKey="Mancini N" first="Nicasio" last="Mancini">Nicasio Mancini</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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